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KCC009 decreased DDC\u2010induced liver enlargement without affecting MB formation or extent of liver injury. TG2 protein and activity increased after DDC feeding and localized within and outside hepatocytes. KCC009 inhibited DDC\u2010induced hepatomegaly by affecting hepatocyte cell size rather than proliferation. Hence, TG2 is a potential mediator of injury\u2010induced hepatomegaly via modulation of hepatocyte hypertrophy, and KCC009\u2010mediated TG2 inhibition does not affect mouse MB formation.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.03.051","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T07:19:59Z","timestamp":1143703199000},"page":"2351-2357","source":"Crossref","is-referenced-by-count":13,"title":["Pharmacologic transglutaminase inhibition attenuates drug\u2010primed liver hypertrophy but not Mallory body formation"],"prefix":"10.1002","volume":"580","author":[{"given":"Pavel","family":"Strnad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Toivola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihang","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon C.","family":"Kosek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaitan","family":"Khosla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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