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Using siRNA\u2010mediated knock\u2010down in macrophages we show that IFN\u2010\u03b2 synthesis in response to transfected, intracellular double\u2010stranded RNA (dsRNA), a pathogen\u2010associated molecular pattern of viruses, is decreased in absence of MAVS. By contrast, the Gram\u2010positive bacterium <jats:italic>Listeria monocytogenes<\/jats:italic> targets the IFN\u2010\u03b2 gene without detectable MAVS requirement. The data show that MAVS is not a central adapter protein for all cytoplasmic pathogen sensors that stimulate IFN\u2010\u03b2 synthesis.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.03.057","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T07:19:59Z","timestamp":1143703199000},"page":"2341-2346","source":"Crossref","is-referenced-by-count":31,"title":["Cytoplasmic <i>Listeria monocytogenes<\/i> stimulates IFN\u2010\u03b2 synthesis without requiring the adapter protein MAVS"],"prefix":"10.1002","volume":"580","author":[{"given":"Didier","family":"Soulat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Bauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Stockinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Superti-Furga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0106-13"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.07.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.06.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1684"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh318"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm909"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1243"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04193"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.08.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200205009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202476699"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6522"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7416"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.3.1602"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.12.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1282"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90188-I"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.13.3660"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.1.91"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.10.986"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1038"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407639101"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1087"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2006.03.057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2006.03.057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:52:22Z","timestamp":1758084742000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2006.03.057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,29]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,4,17]]}},"alternative-id":["10.1016\/j.febslet.2006.03.057"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2006.03.057","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,29]]}}}