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Treatment of CCRF\u2010CEM (T cell acute lymphoblastic leukemia) cells with the GC, dexamethasone (Dex), activates p38\u2010mitogen activated protein kinase (p38\u2010MAPK) and then induces mRNA transcription and synthesis levels of BIM, a BH3\u2010only pro\u2010apoptotic BCL\u20102 family member. Dex\u2010induced apoptosis is dramatically inhibited by downregulation of BIM by shRNA or by pretreatment with a p38\u2010MAPK inhibitor, SB203580, which also reduces BIM induction. These findings indicate that BIM induction through p38\u2010MAPK activation is a critical pathway in GC\u2010induced cell death.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.05.031","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T11:22:17Z","timestamp":1148124137000},"page":"3539-3544","source":"Crossref","is-referenced-by-count":78,"title":["p38\u2010MAP kinase activation followed by BIM induction is essential for glucocorticoid\u2010induced apoptosis in lymphoblastic leukemia cells"],"prefix":"10.1002","volume":"580","author":[{"given":"Jianghua","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Quearry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc883"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02040.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401688"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1568"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406837101"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5445.1735"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401471101"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03845"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208300"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505585102"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.02.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.4.887.887"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90393-M"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4811-9_66"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4811-9_67"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00244-7"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090072"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2853"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411767200"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2023"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301843200"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0528"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(00)00080-7"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2006.05.031","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2006.05.031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T11:12:27Z","timestamp":1697109147000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2006.05.031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,19]]},"references-count":23,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2006,6,12]]}},"alternative-id":["10.1016\/j.febslet.2006.05.031"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2006.05.031","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,19]]}}}