{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:20:37Z","timestamp":1760016037859,"version":"3.32.0"},"reference-count":48,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2006,6,26]]},"abstract":"<jats:p>At present, little is known about signal transduction mechanisms in schistosomes, which cause the disease of schistosomiasis. The mitogen\u2010activated protein kinase (MAPK) signaling pathways, which are evolutionarily conserved from yeast to<jats:italic>Homo sapiens<\/jats:italic>, play key roles in multiple cellular processes. Here, we reconstructed the hypothetical MAPK signaling pathways in<jats:italic>Schistosoma japonicum<\/jats:italic>and compared the schistosome pathways with those of model eukaryote species. We identified 60 homologous components in the<jats:italic>S. japoncium<\/jats:italic>MAPK signaling pathways. Among these, 27 were predicted to be full\u2010length sequences. Phylogenetic analysis of these proteins confirmed the evolutionary conservation of the MAPK signaling pathways. Remarkably, we identified<jats:italic>S. japonicum<\/jats:italic>homologues of GTP\u2010binding protein \u03b2 and \u03b1\u2010I subunits in the yeast mating pathway, which might be involved in the regulation of different life stages and female sexual maturation processes as well in schistosomes. In addition, several pathway member genes, including ERK, JNK, Sja\u2010DSP, MRAS and RAS, were determined through quantitative PCR analysis to be expressed in a stage\u2010specific manner, with ERK, JNK and their inhibitor Sja\u2010DSP markedly upregulated in adult female schistosomes.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.05.055","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T21:13:22Z","timestamp":1149714802000},"page":"3677-3686","source":"Crossref","is-referenced-by-count":22,"title":["Reconstruction and in silico analysis of the MAPK signaling pathways in the human blood fluke,<i>Schistosoma japonicum<\/i>"],"prefix":"10.1002","volume":"580","author":[{"given":"Lili","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fudong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Brindley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongzhi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeguang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.270-295.2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00045-1"},{"key":"e_1_2_7_4_1","first-page":"401","article-title":"Schistosomiasis situation in People&rsquo;s Republic of China in 2003","volume":"16","author":"Xiao D.","year":"2004","journal-title":"Chin. J. Schisto Control."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.143"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(03)00816-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)01893-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1139\/z03-217"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003118209700173X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1236"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1237"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki442"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026334"},{"key":"e_1_2_7_18_1","first-page":"164","article-title":"PHYLIP-phylogeny inference package (version 3.2)","volume":"5","author":"Felsenstein J.","year":"1989","journal-title":"Cladistics"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/5.2.150"},{"key":"e_1_2_7_20_1","first-page":"357","article-title":"Treeview: an application to display phylogenetic trees on personal computers","volume":"12","author":"Page R.D.","year":"1996","journal-title":"Comput. Appl. Biosci."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1997.4150"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065000"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.1.131-139.2003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)00126-H"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.42.29912"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000065"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/fgbi.1998.1102"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.4.1264-1300.1998"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070540"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.4.1135-1150.2003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00205-X"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00117-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49741-X"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0751-z"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.932"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)80044-5"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774462914"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0022-3565(24)39230-4","article-title":"SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence","volume":"293","author":"Underwood D.C.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.412"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(95)00116-I"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00378.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150050207438"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00029-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.807"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(97)01320-6"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.953002"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950180609"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/356604a0"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2006.05.055","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2006.05.055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T07:45:44Z","timestamp":1736408744000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2006.05.055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,6]]},"references-count":48,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2006,6,26]]}},"alternative-id":["10.1016\/j.febslet.2006.05.055"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2006.05.055","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"type":"print","value":"0014-5793"},{"type":"electronic","value":"1873-3468"}],"subject":[],"published":{"date-parts":[[2006,6,6]]}}}