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With the use of specific inhibitors we now show that members of the cytochrome P450 (CYP450) family 4 class are responsible for phytanic acid \u03c9\u2010hydroxylation. Incubations with microsomes containing human recombinant CYP450s (Supersomes\u2122) revealed that multiple CYP450 enzymes of the family 4 class are able to \u03c9\u2010hydroxylate phytanic acid with the following order of efficiency: CYP4F3A &gt; CYP4F3B &gt; CYP4F2 &gt; CYP4A11.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.05.069","type":"journal-article","created":{"date-parts":[[2006,6,11]],"date-time":"2006-06-11T13:31:49Z","timestamp":1150032709000},"page":"3794-3798","source":"Crossref","is-referenced-by-count":22,"title":["Identification of the cytochrome P450 enzymes responsible for the \u03c9\u2010hydroxylation of phytanic acid"],"prefix":"10.1002","volume":"580","author":[{"given":"J.C.","family":"Komen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.A.","family":"Wanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(03)00016-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-190"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-185"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/346093"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2002.00766.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200013338423"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(96)00246-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400510-JLR200"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90760-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300121-JLR200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/29.3.434"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400064-JLR200"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2005.02.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1351"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3470321"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00679.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.6.631"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0090-9556(25)06500-6","article-title":"Cytochrome P450 inhibitors. 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