{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:52Z","timestamp":1791246172849,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T00:00:00Z","timestamp":1158278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2006,10,16]]},"abstract":"<jats:p>The <jats:italic>WFS1<\/jats:italic> gene, encoding an endoplasmic reticulum (ER) membrane glycoprotein, is mutated in Wolfram syndrome characterized by diabetes mellitus and optic atrophy. Herein, Ca<jats:sup>2+<\/jats:sup> dynamics were examined in WFS1\u2010knockdown and \u2010overexpressing HEK293 cells. Studies using ER\u2010targeted Ca<jats:sup>2+<\/jats:sup>\u2010sensitive photoprotein aequorin demonstrated WFS1 protein to positively modulate ER Ca<jats:sup>2+<\/jats:sup> levels by increasing the rate of Ca<jats:sup>2+<\/jats:sup> uptake. Furthermore, Ca<jats:sup>2+<\/jats:sup> imaging with Fura\u20102 showed the magnitude of the store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry to parallel WFS1 expression levels. These data indicate that WFS1 protein participates in the regulation of cellular Ca<jats:sup>2+<\/jats:sup> homeostasis, at least partly, by modulating the filling state of the ER Ca<jats:sup>2+<\/jats:sup> store.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.09.007","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T14:31:35Z","timestamp":1158676295000},"page":"5635-5640","source":"Crossref","is-referenced-by-count":167,"title":["WFS1 protein modulates the free Ca<sup>2+<\/sup> concentration in the endoplasmic reticulum"],"prefix":"10.1002","volume":"580","author":[{"given":"Daisuke","family":"Takei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisamitsu","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0603-135"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01143-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00057.2003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.074134"},{"key":"e_1_2_5_7_1","first-page":"715","article-title":"Diabetes mellitus and simple optic atrophy among siblings: report on four cases","volume":"13","author":"Wolfram D.J.","year":"1938","journal-title":"Mayo. 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