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Here, we show <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> evidence for desensitization\u2010dependent TRPV1 activation in cnidarian envenomations. Cnidarian venom induced a nociceptive reactivity, comparable to capsaicin, in laboratory rats, which could be reduced by the selective TRPV1 antagonist, BCTC. These findings are the first to explain at least part of the symptomology of cnidarian envenomations and provide insights into the design of more effective treatments for this global public health problem.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.09.030","type":"journal-article","created":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T11:29:16Z","timestamp":1159010956000},"page":"5728-5732","source":"Crossref","is-referenced-by-count":73,"title":["Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels"],"prefix":"10.1002","volume":"580","author":[{"given":"Eva","family":"Cuypers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Yanagihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evert","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90105-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2003.tb05040.x"},{"key":"e_1_2_6_4_1","first-page":"125","article-title":"Intravenous ascorbic acid as a treatment for severe jellyfish stings","volume":"23","author":"Kumar S.","year":"2004","journal-title":"P. 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