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We analysed enzymatic and non\u2010enzymatic parameters, and focused on the reduced\/oxidized glutathione and coenzyme Q couples. In lean compared with obese non\u2010diabetic Zucker rats, interscapular brown fat seems well protected against oxidative stress and epididymal adipose tissue shows a more reduced glutathione redox state, associated with a higher susceptibility to lipophilic oxidative stress than inguinal adipose tissue. Epididymal adipose tissue redox metabolism significantly differs from inguinal one by its limited redox metabolism adaptation. Our results demonstrate site\u2010specific managements of reactive oxygen species metabolism in obese Zucker rats. These results are not consistent with the classic deciphering of inflammatory situation and produce a new conception of the redox parameters implication in the development of the metabolic syndrome.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.10.052","type":"journal-article","created":{"date-parts":[[2006,11,4]],"date-time":"2006-11-04T12:14:00Z","timestamp":1162642440000},"page":"6391-6398","source":"Crossref","is-referenced-by-count":36,"title":["Site specific changes of redox metabolism in adipose tissue of obese Zucker rats"],"prefix":"10.1002","volume":"580","author":[{"given":"Anne","family":"Galinier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Carriere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Caspar-Bauguil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Periquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Periquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Penicaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Casteilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0580"},{"key":"e_1_2_5_3_1","first-page":"291","article-title":"The regulation of adipose tissue distribution in humans","volume":"20","author":"Bjorntorp P.","year":"1996","journal-title":"Int. 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