{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:17:11Z","timestamp":1790011031607,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2006,11,27]]},"abstract":"<jats:p>Abl interactor (Abi) was identified as an Abl tyrosine kinase\u2010binding protein and subsequently shown to be a component of the macromolecular Abi\/WAVE complex, which is a key regulator of Rac\u2010dependent actin polymerization. Previous studies showed that Abi\u20101 promotes c\u2010Abl\u2010mediated phosphorylation of Mammalian Enabled (Mena) and WAVE2. In addition to Abi\u20101, mammals possess Abi\u20102 and NESH (Abi\u20103). In this study, we compared the three Abi proteins in terms of the promotion of c\u2010Abl\u2010mediated phosphorylation and the formation of Abi\/WAVE complex. Although Abi\u20102, like Abi\u20101, promoted the c\u2010Abl\u2010mediated phosphorylation of Mena and WAVE2, NESH (Abi\u20103) had no such effect. This difference was likely due to their binding abilities as to c\u2010Abl. Immunoprecipitation revealed that NESH (Abi\u20103) is present in the Abi\/WAVE complex. Our results suggest that NESH (Abi\u20103), like Abi\u20101 and Abi\u20102, is a component of the Abi\/WAVE complex, but likely plays a different role in the regulation of c\u2010Abl.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.10.065","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T12:29:04Z","timestamp":1162988944000},"page":"6464-6470","source":"Crossref","is-referenced-by-count":24,"title":["NESH (Abi\u20103) is present in the Abi\/WAVE complex but does not promote c\u2010Abl\u2010mediated phosphorylation"],"prefix":"10.1002","volume":"580","author":[{"given":"Noriko","family":"Hirao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Maruoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Shishido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Tani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.21.2583"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.21.2569"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90554-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301447200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.5.521"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81341-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.19.050103.103356"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409120102"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02254375"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.04.052"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00859"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.10.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600084"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1105"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400628101"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(00)00158-5"},{"key":"e_1_2_6_18_1","first-page":"91","article-title":"In search of a function for the E3B1\/Abi2\/Argbp1\/NESH family","volume":"95","author":"Ichigotani Y.","year":"2002","journal-title":"Int. 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