{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:44:56Z","timestamp":1791164696363,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2006,11,27]]},"abstract":"<jats:p>Genes including DM domain regulate sexual development in diverse metazoan phyla. One of these genes, <jats:italic>Dmrt7<\/jats:italic>, was expressed only in testes of adult mice. To determine the role of <jats:italic>Dmrt7<\/jats:italic> in mice, we generated <jats:italic>Dmrt7<\/jats:italic>\u2010knockout mice (<jats:italic>Dmrt7<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup>). Although the <jats:italic>Dmrt7<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup> showed normal growth, null males were infertile. No sperm was detected in the epididymis of <jats:italic>Dmrt7<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup> adult males. Absence of spermatids in a histological analysis, decreased expression of <jats:italic>Ccna1<\/jats:italic> mRNA and the accumulation of SCP3\u2010positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the <jats:italic>Dmrt7<\/jats:italic>\u2010knockout mice.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.10.066","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T12:29:04Z","timestamp":1162988944000},"page":"6442-6446","source":"Crossref","is-referenced-by-count":40,"title":["Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage"],"prefix":"10.1002","volume":"580","author":[{"given":"Masaki","family":"Kawamata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Nishimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35056032"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90633-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90117-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35618"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature751"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9461"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.834100"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.11.027"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-133X(02)00071-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01914-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05684.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505123103"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.1.53"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9156"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/3855"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.8.1611"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.107.10.2749"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04112"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2006.10.066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2006.10.066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T21:31:37Z","timestamp":1697146297000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2006.10.066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,7]]},"references-count":19,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2006,11,27]]}},"alternative-id":["10.1016\/j.febslet.2006.10.066"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2006.10.066","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,7]]}}}