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Here, we demonstrated that, among five accessory proteins of SARS coronavirus (SARS\u2010CoV) tested, 3a\/X1 and 7a\/X4 were capable of activating nuclear factor kappa B (NF\u2010\u03baB) and <jats:italic>c<\/jats:italic>\u2010Jun <jats:italic>N<\/jats:italic>\u2010terminal kinase (JNK), and significantly enhanced interleukin 8 (IL\u20108) promoter activity. Furthermore, 3a\/X1 and 7a\/X4 expression in A549 cells enhanced production of inflammatory chemokines that were known to be up\u2010regulated in SARS\u2010CoV infection. Our results suggest potential involvement of 3a\/X1 and 7a\/X4 proteins in the pathological inflammatory responses in SARS.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.11.046","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T10:30:24Z","timestamp":1164709824000},"page":"6807-6812","source":"Crossref","is-referenced-by-count":111,"title":["Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a\/X1 and 7a\/X4 proteins through NF\u2010\u03baB 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