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Our cDNA microarray analysis revealed that expression of early growth response gene\u20101 (Egr\u20101) was increased by LMP1 expression in MCF7 and Jurkat cells. An NF\u03baB inhibitor (SN50) antagonized LMP1\u2010induced enhancement of Egr\u20101 expression, indicating that LMP1 induced Egr\u20101 via NF\u03baB. Furthermore, three lines of evidence indicated that Egr\u20101 was required for LMP1\u2010induced cancer cell survival. First, Egr\u20101 expression enhanced the survival of doxorubicin\u2010treated MCF7 cells. Second, inhibition of Egr\u20101 expression by siRNA (siEgr\u20101) effectively suppressed LMP\u20101\u2010induced survival of MCF7 cells. Third, Egr\u20101 knockdown decreased LMP1\u2010induced expression of Bfl\u20101. Similar relationships among EBV infection, Egr\u20101 and drug resistance were also observed in tissues of peripheral T\u2010cell lymphoma\u2010unspecified (PTCL\u2010u) patients.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.01.020","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T12:18:45Z","timestamp":1169209125000},"page":"623-628","source":"Crossref","is-referenced-by-count":21,"title":["Egr\u20101, a new downstream molecule of Epstein\u2010Barr virus latent membrane protein 1"],"prefix":"10.1002","volume":"581","author":[{"given":"Joo Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Yeong","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hyeh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaehwa","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902233200806"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-006-0081-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00028-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420305"},{"key":"e_1_2_6_6_1","first-page":"769","article-title":"Epstein-Barr virus-associated gastric adenocarcinoma","volume":"140","author":"Shibata D.","year":"1992","journal-title":"J. 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