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We show that the last 74 C\u2010terminal residues of IpaA (A559) bind to human vinculin (HV) and promotes its association with actin filaments. Polymerisation experiments demonstrated that A559 was sufficient to induce HV\u2010dependent partial capping of the barbed ends of actin filaments. These results suggest that IpaA regulates actin polymerisation\/depolymerisation at sites of <jats:italic>Shigella<\/jats:italic> invasion by modulating the barbed end capping activity of vinculin.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.01.057","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T16:02:37Z","timestamp":1170691357000},"page":"853-857","source":"Crossref","is-referenced-by-count":53,"title":["Capping of actin filaments by vinculin activated by the <i>Shigella<\/i> IpaA carboxyl\u2010terminal domain"],"prefix":"10.1002","volume":"581","author":[{"given":"Nalini","family":"Ramarao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Le 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