{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:40:25Z","timestamp":1778110825180,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2007,3,20]]},"abstract":"<jats:p>\n<jats:italic>GTF2IRD1<\/jats:italic> is a member of a family of transcription factors whose defining characteristic is varying numbers of a helix\u2013loop\u2013helix like motif, the I\u2010repeat. Here, we present functional analysis of human GTF2IRD1 in regulation of three genes (<jats:italic>HOXC8<\/jats:italic>, <jats:italic>GOOSECOID<\/jats:italic> and <jats:italic>TROPONIN I<\/jats:italic>\n<jats:sub>\n<jats:italic>SLOW<\/jats:italic>\n<\/jats:sub>). We define a regulatory motif (GUCE\u2013GTF2IRD1 Upstream Control Element) common to all three genes. GUCE is bound in vitro by domain I\u20104 of GTF2IRD1 and mediates transcriptional regulation by GTF2IRD1 in vivo. Definition of this site will assist in identification of other downstream targets of GTF2IRD1 and elucidation of its role in the human developmental disorder Williams\u2013Beuren syndrome.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.02.040","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:27:30Z","timestamp":1172784450000},"page":"1233-1242","source":"Crossref","is-referenced-by-count":16,"title":["GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif \u2018GUCE\u2019"],"prefix":"10.1002","volume":"581","author":[{"given":"P.D.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hinsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Jowitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Sharrocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tassabehji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3226"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116142"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.7.526"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892900562002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000076975.10224.67"},{"key":"e_1_2_7_7_1","first-page":"478","article-title":"Detection of an atypical 7ql 1.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes","volume":"36","author":"Botta A.","year":"1999","journal-title":"J. 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