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The pharmacological effects of BoiTx1 were studied on various cloned K<jats:sup>+<\/jats:sup> channels expressed in <jats:italic>Xenopus laevis<\/jats:italic> oocytes. BoiTx1 inhibited currents through <jats:italic>Drosophila Shaker<\/jats:italic> channels with an IC<jats:sub>50<\/jats:sub> value of 3.5 \u00b1 0.5 nM, yet had much lesser effect on its mammalian orthologs. Thus, BoiTx1 is the first member of the \u03b1\u2010KTx3 family that preferentially affects insect potassium channels.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.04.065","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T11:10:45Z","timestamp":1178017845000},"page":"2478-2484","source":"Crossref","is-referenced-by-count":27,"title":["Isolation of the first toxin from the scorpion <i>Buthus occitanus israelis<\/i> showing preference for <i>Shaker<\/i> potassium channels"],"prefix":"10.1002","volume":"581","author":[{"given":"Adi","family":"Kozminsky-Atias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Somech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Zilberberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/296090a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02907789"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00157-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)94035-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2004.03.022"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01398-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.12.073"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00080-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569549409006481"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(72)90004-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(71)80195-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00188a012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)30067-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041379"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(99)00137-3"},{"key":"e_1_2_6_17_1","unstructured":"Levi G. and Amitai P. 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