{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:58:34Z","timestamp":1791298714007,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2007,6,19]]},"abstract":"<jats:p>\n<jats:italic>Legionella pneumophila<\/jats:italic> is the causative agent of the pneumonia\u2010like Legionnaires\u2019 disease. The bacterium's survival and spread depend on the ability to replicate inside eukaryotic phagocytic cells. A particular feature of <jats:italic>Legionella<\/jats:italic> is its dual host system allowing the intracellular growth in protozoa like <jats:italic>Acanthamoeba castellanii<\/jats:italic>, and during infection in human alveolar macrophages. Genome analysis and comparisons as well as expression profiling of the pathogen and the host helped to identify regulatory circuits mediating adaptation of the <jats:italic>L. pneumophila<\/jats:italic> transcriptome to the intracellular environment and gave clues for the metabolic needs of intracellular <jats:italic>Legionella<\/jats:italic>. This review will summarize what is currently known about intracellular gene expression of <jats:italic>L. pneumophila<\/jats:italic>, the transcriptional host response of the model host <jats:italic>Dictyostelium discoideum<\/jats:italic> and will present hypotheses drawn from these data with respect to subversion of host cell functions and virulence of <jats:italic>L. pneumophila<\/jats:italic>.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.05.026","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T11:54:13Z","timestamp":1179921253000},"page":"2829-2838","source":"Crossref","is-referenced-by-count":56,"title":["<i>Legionella pneumophila<\/i> adaptation to intracellular life and the host response: Clues from genomics and transcriptomics"],"prefix":"10.1002","volume":"581","author":[{"given":"Matthieu","family":"Jules","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Buchrieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200205011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1669"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06177.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094226"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304916101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.05.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1463"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.7.3029-3034.1998"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04129.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1447"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099776"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03481"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00703.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00633.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.03.009"},{"key":"e_1_2_8_19_1","unstructured":"2006 ASM Press Washington DC C. 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