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Meanwhile, intravenous injection of Harobin leads to the reduction of blood pressure in SHR rats. It results from the ability of Harobin that cleaves angiotensin I and release bradykinin from plasma kininogen in vitro and in vivo. These data suggest that Harobin is a novel defibrase and has a potential to be an agent for the therapy of thrombosis and hypertension.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.05.047","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T11:58:01Z","timestamp":1180526281000},"page":"2965-2973","source":"Crossref","is-referenced-by-count":37,"title":["Identification and characterization of Harobin, a novel fibrino(geno)lytic serine protease from a sea snake (<i>Lapemis hardwickii<\/i>)"],"prefix":"10.1002","volume":"581","author":[{"given":"Junyun","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00268-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(93)90004-N"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32967-6_8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1949.156.2.261"},{"key":"e_1_2_6_6_1","first-page":"689","article-title":"Jerdonase, a novel serine protease with kinin-releasing and fibrinogenolytic activity from Trimeresurus jerdonii venom","volume":"35","author":"Jia Y.H.","year":"2003","journal-title":"Acta Biochim. 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