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In the present study, we found that application of fenofibrate and overexpression of PPAR\u2010\u03b1 inhibited endothelin\u20101 (ET\u20101)\u2010induced phosphorylation of protein kinase B (Akt) at Ser473 and glycogen synthase kinase3\u03b2 (GSK3\u03b2) at Ser9, and prevented ET\u20101\u2010induced nuclear translocation of NFATc4 in cardiomyocytes. Moreover, co\u2010immunoprecipitation studies showed that fenofibrate strongly induced the association of nuclear factor of activated T cells (NFATc4) with PPAR\u2010\u03b1. These results suggest that activation of PPAR\u2010\u03b1 inhibits ET\u20101\u2010induced cardiac hypertrophy through regulating PI3K\/Akt\/GSK3\u03b2 and NFAT signaling pathways.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.06.017","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T11:19:08Z","timestamp":1182338348000},"page":"3311-3316","source":"Crossref","is-referenced-by-count":37,"title":["Activation of peroxisome proliferator\u2010activated receptor\u2010\u03b1 prevents glycogen synthase 3\u03b2 phosphorylation and inhibits cardiac hypertrophy"],"prefix":"10.1002","volume":"581","author":[{"given":"Ruifang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongbiao","family":"Pi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00677.2004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464002-00003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9056"},{"key":"e_1_2_7_5_1","first-page":"49","article-title":"Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart","volume":"8","author":"Karbowska J.","year":"2003","journal-title":"Cell Mol. 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