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We have now characterized the guanine nucleotide exchange factor epithelial cell\u2010transforming gene 2 (ECT2) as a PB\u2010inducible factor as well as a cellular signal that represses PB\u2010triggered nuclear translocation of CAR. When CFP\u2010tagged ECT2 was co\u2010expressed with YFP\u2010tagged CAR in the liver of <jats:italic>Car<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup> mice, ECT2 repressed CAR nuclear translocation. Coexpression of various deletion mutants delineated this repressive activity to the tandem Dbl homology\/pleckstrin homology domains of ECT2 and to their cytosolic expression. CAR directly bound to the PH domain. Thus, ECT2 may comprise a part of the PB response signal regulating the intracellular trafficking of CAR.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.09.024","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T17:16:46Z","timestamp":1190999806000},"page":"4937-4942","source":"Crossref","is-referenced-by-count":9,"title":["Overexpression of the Rho\u2010guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver"],"prefix":"10.1002","volume":"581","author":[{"given":"Fardin","family":"Hosseinpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.10.5652"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6043"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35038112"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.1.1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00456-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.18.7931-7940.2004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510713200"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.112706"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1459"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.9.6318"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2006.12.006"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.11.028"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/362462a0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1846048"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003780200"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.2.425-437.2001"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211792200"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10688"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306725200"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.8.2838-2846.2001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407281200"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90519-2"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.8.4158"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313792200"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.10.070"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.034538"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2007.09.024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2007.09.024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:05:16Z","timestamp":1697155516000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2007.09.024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,21]]},"references-count":26,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2007,10,16]]}},"alternative-id":["10.1016\/j.febslet.2007.09.024"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2007.09.024","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,21]]}}}