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In dopaminergic cells, DA exposure increased quinoproteins and decreased cell viability; these were ameliorated by pretreatment with MT\u2010inducer zinc. Repeated L\u2010DOPA administration markedly elevated striatal quinoprotein levels and reduced the DA nerve terminals specifically on the lesioned side in MT\u2010knockout parkinsonian mice, but not in wild\u2010type mice. Our results suggested that intrinsic MT protects against L\u2010DOPA\u2010induced DA quinone neurotoxicity in parkinsonian mice by its quinone\u2010quenching property.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.09.046","type":"journal-article","created":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T17:59:50Z","timestamp":1191261590000},"page":"5003-5008","source":"Crossref","is-referenced-by-count":42,"title":["Protective effects of metallothionein against dopamine quinone\u2010induced dopaminergic neurotoxicity"],"prefix":"10.1002","volume":"581","author":[{"given":"Ikuko","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Asanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Hozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Sogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,29]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"633","article-title":"Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones","volume":"14","author":"Graham D.G.","year":"1978","journal-title":"Mol. 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