{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:00:40Z","timestamp":1761393640029},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2008,1,23]]},"abstract":"<jats:p>Non\u2010bullous congenital ichthyosis erythroderma (NCIE) and lamellar ichthyosis (LI) are characterized by mutations in 12<jats:italic>R<\/jats:italic>\u2010lipoxygenase (12<jats:italic>R<\/jats:italic>\u2010LOX) and\/or epidermal lipoxygenase 3 (eLOX3) enzymes. The eLOX3 lacks oxygenase activity, but is capable of forming hepoxilin\u2010type products from arachidonic acid\u2010derived hydroperoxide from 12<jats:italic>R<\/jats:italic>\u2010LOX, termed 12<jats:italic>R<\/jats:italic>\u2010hydroperoxyeicosa\u20105,8,10,14\u2010tetraenoic acid (12<jats:italic>R<\/jats:italic>\u2010HpETE). Mutations in either of two enzymes lead to NCIE or LI. Moreover, 12<jats:italic>R<\/jats:italic>\u2010LOX\u2010deficient mice exhibit severe phenotypic water barrier dysfunctions. Here, we demonstrate that 12<jats:italic>R<\/jats:italic>\u2010HpETE can also be transformed to 8<jats:italic>R<\/jats:italic>\u2010HXA<jats:sub>3<\/jats:sub> by hepoxilin A<jats:sub>3<\/jats:sub> (HXA<jats:sub>3<\/jats:sub>) synthase (12\u2010lipoxygenase), which exhibits oxygenase activity. We also presented a novel form of ichthyosis in a patient, termed hepoxilin A<jats:sub>3<\/jats:sub> synthase\u2010linked ichthyosis (HXALI), whose scales expressed high levels of 12<jats:italic>R<\/jats:italic>\u2010LOX, but were deficient of HXA<jats:sub>3<\/jats:sub> synthase.<\/jats:p>","DOI":"10.1016\/j.febslet.2007.12.017","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T16:27:00Z","timestamp":1198081620000},"page":"279-285","source":"Crossref","is-referenced-by-count":5,"title":["Hepoxilin A<sub>3<\/sub> (HXA<sub>3<\/sub>) synthase deficiency is causative of a novel ichthyosis form"],"prefix":"10.1002","volume":"582","author":[{"given":"Santosh","family":"Nigam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Patapia","family":"Zafiriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupal","family":"Deva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Kerstin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Geilen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Ciccoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Sczepanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"H. 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