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Ang II did not suppress food intake in AT<jats:sub>2<\/jats:sub> receptor\u2010knockout mice, while it did significantly in wild\u2010type and AT<jats:sub>1<\/jats:sub> receptor\u2010knockout mice. The suppression of food intake in AT<jats:sub>1<\/jats:sub> receptor\u2010knockout mice was smaller than that in wild\u2010type. The anorexigenic activities of Ang II and III were also blocked by a selective antagonist for prostaglandin EP<jats:sub>4<\/jats:sub> receptor. Taken together, centrally administered Ang II and III may decrease food intake through AT<jats:sub>2<\/jats:sub> receptor with partial involvement of AT<jats:sub>1<\/jats:sub> receptor, followed by EP<jats:sub>4<\/jats:sub> receptor activation, which is a novel pathway regulating food intake.<\/jats:p>","DOI":"10.1016\/j.febslet.2008.01.054","type":"journal-article","created":{"date-parts":[[2008,2,7]],"date-time":"2008-02-07T12:22:02Z","timestamp":1202386922000},"page":"773-777","source":"Crossref","is-referenced-by-count":24,"title":["Angiotensin II and III suppress food intake via angiotensin AT<sub>2<\/sub> receptor and prostaglandin EP<sub>4<\/sub> receptor in mice"],"prefix":"10.1002","volume":"582","author":[{"given":"Kousaku","family":"Ohinata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-006-0190-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00381-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/351233a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74499-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74498-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.2004.00184.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00019-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-005-4011-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(79)90177-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03676-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00537.2003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.11.1907936"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/26233"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-14-05975.2003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1964.tb01558.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(81)90014-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1193"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113455"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.11.020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2006.06.008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71865-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715120-00016"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.4.7405"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.18719"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/377744a0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00588-5"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.07.009"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00368-0"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00220-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00515.2002"},{"key":"e_1_2_6_32_1","unstructured":"Yamada Y. 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