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A TBK1 binding site was located between residues 1\u2010127 of OPTN, residues 78\u2010121 displaying striking homology to the TBK1\u2010binding domain of TANK. The OPTN\u2010binding domain was localised to residues 601\u2010729 of TBK1, while TBK1[1\u2010688] which cannot bind to TANK, did not interact with OPTN. 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