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Addition of non\u2010cytotoxic concentrations of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> did not affect mRNA expression levels and activity of cathepsins, while the catalase activity remained also unchanged, consistently with RT\u2010PCR analysis. Conversely inhibition of extracellular catalase led to a striking inactivation of secreted cysteine cathepsins by H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. This report suggests that catalase may participate in the protection of extracellular cysteine proteases against peroxidation.<\/jats:p>","DOI":"10.1016\/j.febslet.2008.03.007","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T14:35:29Z","timestamp":1205591729000},"page":"1307-1312","source":"Crossref","is-referenced-by-count":24,"title":["Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide"],"prefix":"10.1002","volume":"582","author":[{"given":"Virginie","family":"Herv\u00e9-Gr\u00e9pinet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Veillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Godat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Heuz\u00e9-Vourc'h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Lecaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lalmanach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.11.5080"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2004.020"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200106000-00004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2206007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4675"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.2.471"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-029SR"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.07.024"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.12.013"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2092"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0101656"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207779313542"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203013381170"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.09.011"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(03)00174-1"},{"key":"e_1_2_5_17_1","unstructured":"Godat E. 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