{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:53:57Z","timestamp":1791071637055,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2008,4,30]]},"abstract":"<jats:p>\n                    Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA\u2010related kinases (NRKs) are conserved serine\/threonine kinases, which are usually defined as \u2018mitotic kinases\u2019. Murine mutants for the NRKs,\n                    <jats:italic>nek1<\/jats:italic>\n                    (\n                    <jats:italic>kat<\/jats:italic>\n                    mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin\u2013Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in\n                    <jats:italic>kat2J<\/jats:italic>\n                    mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2008.03.036","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T09:09:54Z","timestamp":1207127394000},"page":"1465-1470","source":"Crossref","is-referenced-by-count":103,"title":["The mammalian Nek1 kinase is involved in primary cilium formation"],"prefix":"10.1002","volume":"582","author":[{"given":"Ohad","family":"Shalom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nechama","family":"Shalva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Altschuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Motro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0462"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02030"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214099"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1217"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg274"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000029587.47950.25"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(03)00056-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001076"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00227-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1747-1028-2-25"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02900"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02455"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-05-0450"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.217"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V10122534"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.1.7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.01.009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080824"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00173"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020136"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2008.03.036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2008.03.036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T17:38:33Z","timestamp":1697132313000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2008.03.036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,4,30]]}},"alternative-id":["10.1016\/j.febslet.2008.03.036"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2008.03.036","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}