{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:18:04Z","timestamp":1790972284518,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T00:00:00Z","timestamp":1213747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2008,7,23]]},"abstract":"<jats:p>Neostatin\u20107, with an anti\u2010angiogenic potential, is generated from the proteolytic action of matrix metalloproteinase\u20107 on collagen XVIII. We previously reported that neostatin\u20107 inhibited angiogenesis in vitro and in vivo. Here we demonstrate that neostatin\u20107\/collagen XVIII may possess anti\u2010lymphangiogenic activities by: (1) corneal micropellet implantation of neostatin\u20107 reduced bFGF\u2010induced corneal lymphangiogenesis; (2) neostatin\u20107 bound to VEGF receptor\u20103 in vitro; and (3) enhanced corneal lymphangiogenesis and VEGF\u2010C expression in collagen XVIII knockout mice in a corneal wounding model. Understanding the mechanism of neostatin\u20107\/collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis\u2010related disorders, such as lymphedema, transplantation rejection and cancers.<\/jats:p>","DOI":"10.1016\/j.febslet.2008.06.014","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T08:23:56Z","timestamp":1213863836000},"page":"2515-2520","source":"Crossref","is-referenced-by-count":38,"title":["Neostatin\u20107 regulates bFGF\u2010induced corneal lymphangiogenesis"],"prefix":"10.1002","volume":"582","author":[{"given":"Takashi","family":"Kojima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri T.","family":"Azar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2006.4.83"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2003.10.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4576"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05249"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506112103"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/75997"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.12.3793"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0408"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3567"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203855"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.15.4249"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02249-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0884"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81848-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.05.043"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.11.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202771200"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1126391"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1078"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1458"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02897-6"},{"key":"e_1_2_6_24_1","first-page":"1625","article-title":"A model of angiogenesis in the mouse cornea","volume":"37","author":"Kenyon B.M.","year":"1996","journal-title":"Invest. 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