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We find that MA inhibits growth of T\u2010cell leukemia and chronic myelogenous leukemia cells in a time\u2010 and dose\u2010dependent manner. Accumulation of cells in the subG1 peak, annexin V binding and DNA fragmentation suggested induction of apoptosis. Besides, upregulation of BAD (proapoptotic) and downregulation of BCL2 (antiapoptotic) gene products further supported induction of apoptosis. Loss of mitochondrial membrane potential, activation of caspase 9, caspase 3, cleavage of PARP, downregulation of Ku70\/80 and phosphorylation of MAP kinases suggested that MA could induce intrinsic pathway of apoptosis in leukemic cells.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2008.11.001","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T04:25:08Z","timestamp":1227846308000},"page":"4066-4076","source":"Crossref","is-referenced-by-count":66,"title":["Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells"],"prefix":"10.1002","volume":"582","author":[{"given":"Kishore K.","family":"Chiruvella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi","family":"Kari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibha","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mridula","family":"Nambiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama Gopal","family":"Ghanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathees C.","family":"Raghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20353"},{"key":"e_1_2_7_3_1","article-title":"Chromosomal translocations in cancer","author":"Nambiar M.","year":"2008","journal-title":"Biochim. 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