{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:02:46Z","timestamp":1772042566812,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T00:00:00Z","timestamp":1228521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2009,1,5]]},"abstract":"<jats:p>Alternative oxidase (AOX) plays a pivotal role in cyanide\u2010resistance respiration in the mitochondria of plants, fungi and some protists. Here we show that AOX from thermogenic skunk cabbage successfully conferred cyanide resistance to human cells. In galactose medium, HeLa cells with mitochondria\u2010targeted AOX proteins were found to have significantly less reactive oxygen species production in response to antimycin\u2010A exposure, a specific inhibitor of respiratory complex III. These results suggest that skunk cabbage AOX can be used to create an alternative respiration pathway, which might be important for therapy against various mitochondrial diseases.<\/jats:p>","DOI":"10.1016\/j.febslet.2008.11.040","type":"journal-article","created":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T09:40:51Z","timestamp":1228642851000},"page":"148-152","source":"Crossref","is-referenced-by-count":16,"title":["Functional expression of plant alternative oxidase decreases antimycin A\u2010induced reactive oxygen species production in human cells"],"prefix":"10.1002","volume":"583","author":[{"given":"Kazushige","family":"Matsukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikukatsu","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/FP08025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027388729586"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.075523"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.107.113563"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2008.04.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8271"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027374931887"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407715200"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1482"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400601"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.061"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.89.4.1311"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70.1046"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/358325a0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109853200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.65.4.669"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06734"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.02.072"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi002368e"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/35055095"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.01.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.12.019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.276.2.C507"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-23-09060.1997"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00043-X"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2004.07.007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.04.015"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2007.06.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2004.07.028"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2008.04.007"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2007.02.001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.06.004"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2008.11.040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2008.11.040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:44:22Z","timestamp":1697139862000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2008.11.040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,6]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,5]]}},"alternative-id":["10.1016\/j.febslet.2008.11.040"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2008.11.040","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,6]]}}}