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Following preferential partitioning of IAPP into the fluid lipid phase, the membrane suffers irreversible damage and predominantly circularly\u2010shaped lipid\u2010containing IAPP amyloid is formed. Interaction studies with the pancreatic \u03b2\u2010cell line INS\u20101E revealed that growing IAPP fibrils also incorporate substantial amounts of cellular membranes in vivo. 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