{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:33:09Z","timestamp":1776353589121,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T00:00:00Z","timestamp":1242259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2009,6,18]]},"abstract":"<jats:p>A full\u2010length cDNA encoding an anticoagulant peptide, named AduNAP4, was cloned and identified from the human hookworm <jats:italic>Ancylostoma duodenale<\/jats:italic>. AduNAP4 has 104 amino acids including a predicted 23\u2010residue signal peptide and shows \u2a7d50% similarity with other known nematode anticoagulant protein\/peptide (NAP). AduNAP4 is extremely efficient at prolonging the activated partial thromboplastin time, and is an inhibitor of both fXa (<jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub>\n= 7.34 \u00b1 1.74 nM) and fXIa (<jats:italic>K<\/jats:italic>\n<jats:sub>i<\/jats:sub>\n= 42.45 \u00b1 3.25 nM). No fXIa inhibitor has previously been described from other blood\u2010feeding animals. Our results suggest that hookworms have evolved a potent mechanism that interferes with coagulation by inhibition of fXIa to facilitate its blood\u2010feeding lifestyle.<\/jats:p>","DOI":"10.1016\/j.febslet.2009.05.009","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T15:27:38Z","timestamp":1242401258000},"page":"1976-1980","source":"Crossref","is-referenced-by-count":35,"title":["An anticoagulant peptide from the human hookworm, <i>Ancylostoma duodenale<\/i> that inhibits coagulation factors Xa and XIa"],"prefix":"10.1002","volume":"583","author":[{"given":"Weiqiong","family":"Gan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013985911759"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31819091dc"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000224843.33216.5f"},{"key":"e_1_2_6_5_1","first-page":"281","article-title":"Blood sucking activities of hookworms. 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