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The lung fluke <jats:italic>Paragonimus<\/jats:italic> <jats:italic>westermani<\/jats:italic> has a contiguous two\u2010domain TK with a mass of 80 216 Da consisting of 713 amino acid residues sharing higher sequence identity with molluscan arginine kinase (AK). Both domains of <jats:italic>P. westermani<\/jats:italic> TK have significant activity for the substrate taurocyamine and exhibited synergism during substrate binding. Since TK plays a key role in energy metabolism and is not present in mammals, inhibitors against <jats:italic>P. westermani<\/jats:italic> TK could be effective novel chemotherapeutic agents and could be utilized for the development of specific diagnostic tools for the detection of paragonimiasis.<\/jats:p>","DOI":"10.1016\/j.febslet.2009.05.049","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T08:24:07Z","timestamp":1244103847000},"page":"2218-2224","source":"Crossref","is-referenced-by-count":24,"title":["Molecular characterization and kinetic properties of a novel two\u2010domain taurocyamine kinase from the lung fluke <i>Paragonimus westermani<\/i>"],"prefix":"10.1002","volume":"583","author":[{"given":"Blanca R.","family":"Jarilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tokuhiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Nagataki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Uda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Agatsuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.289"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2003.11.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2005.10.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-2647(74)90010-0"},{"key":"e_1_2_7_6_1","first-page":"199","volume-title":"Homologous Enzymes and Biochemical Evolution","author":"Thoai V.N.","year":"1968"},{"key":"e_1_2_7_7_1","first-page":"457","volume-title":"The Enzymes","author":"Morrison J.F.","year":"1973"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.11.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2005.08.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1495"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02473-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21557"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01171-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.03.015"},{"key":"e_1_2_7_15_1","first-page":"41","article-title":"Cloning and enzyme activity of a recombinant phosphagen kinase from nematode","volume":"57","author":"Nagataki M.","year":"2008","journal-title":"Jpn. 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