{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:45:04Z","timestamp":1779119104732,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,10,31]],"date-time":"2009-10-31T00:00:00Z","timestamp":1256947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2010,1,4]]},"abstract":"<jats:p>Cardiac myocyte growth is under differential control of mammalian target of rapamycin (mTOR) and glycogen\u2010synthase\u2010kinase\u20103<jats:italic>\u03b2<\/jats:italic> (GSK3<jats:italic>\u03b2<\/jats:italic>). Whereas active GSK3<jats:italic>\u03b2<\/jats:italic> negatively regulates growth and down\u2010regulates cellular protein synthesis, activation of the mTOR pathway promotes protein expression and cell growth. Here we report that depletion of mTOR via siRNA mediated knockdown causes marked down\u2010regulation of GSK3<jats:italic>\u03b2<\/jats:italic> protein in cardiac myocytes. As a result, GSK3<jats:italic>\u03b2<\/jats:italic> target protein <jats:italic>\u03b2<\/jats:italic>\u2010catenin becomes stabilized and translocates into the nucleus. Moreover, mTOR knockdown leads to increase in cardiac myocyte surface area and produces an up\u2010regulation of the fetal gene program. Our findings suggest a new type of convergence of mTOR and GSK3<jats:italic>\u03b2<\/jats:italic> activities, indicating that GSK3<jats:italic>\u03b2<\/jats:italic>\u2010dependent stabilization of <jats:italic>\u03b2<\/jats:italic>\u2010catenin in cardiac myocytes is influenced by mTOR.<\/jats:p>","DOI":"10.1016\/j.febslet.2009.10.080","type":"journal-article","created":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T09:11:24Z","timestamp":1257066684000},"page":"74-80","source":"Crossref","is-referenced-by-count":8,"title":["Depletion of mammalian target of rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of <i>\u03b2<\/i>\u2010catenin and elicits distinct features of cardiomyocyte hypertrophy"],"prefix":"10.1002","volume":"584","author":[{"given":"Marco","family":"Hagenmueller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratima","family":"Malekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Fieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine S.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian J.","family":"Buss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan 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