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The present knowledge on both \u201ccanonical\u201d and \u201cdeviating\u201d signature motifs retrieved from vertical and horizontal sequence comparisons is briefly reviewed. Novel characteristics, proper to tRNAs from a given translation system, are revealed by a case study on the nuclear and organellar tRNA sets from malaria\u2010related organisms. Unprecedented distinctive features for <jats:italic>Plasmodium falciparum<\/jats:italic> apicoplastic tRNAs appear, which provide novel routes to be explored towards anti\u2010malarial drugs. 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