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PCSK9 and LDLR are also expressed in insulin\u2010producing pancreatic islet \u03b2 cells, possibly affecting the function of these cells. Here we show that, compared to control mice, PCSK9\u2010null male mice over 4 months of age carried more LDLR and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose\u2010intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. Collectively, these observations suggest that PCSK9 may be necessary for the normal function of pancreatic islets.<\/jats:p>","DOI":"10.1016\/j.febslet.2009.12.018","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T13:42:25Z","timestamp":1261057345000},"page":"701-706","source":"Crossref","is-referenced-by-count":177,"title":["PCSK9\u2010deficient mice exhibit impaired glucose tolerance and pancreatic islet 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