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FeoB consists of a membrane\u2010embedded core and an N\u2010terminal, cytosolic region (NFeoB). Here, we report the crystal structure of NFeoB from <jats:italic>L. pneumophila<\/jats:italic>, revealing a monomeric protein comprising two separate domains with GTPase and guanine\u2010nucleotide dissociation inhibitor (GDI) functions. The GDI domain displays a novel fold, whereas the overall structure of the GTPase domain resembles that of known G domains but is in the rarely observed nucleotide\u2010free state.<\/jats:p>","DOI":"10.1016\/j.febslet.2009.12.045","type":"journal-article","created":{"date-parts":[[2009,12,28]],"date-time":"2009-12-28T09:02:45Z","timestamp":1261990965000},"page":"733-738","source":"Crossref","is-referenced-by-count":32,"title":["Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of <i>Legionella pneumophila<\/i>"],"prefix":"10.1002","volume":"584","author":[{"given":"Nele","family":"Petermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Hilgenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.506-526.2002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0901-779"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410820200"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.02.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.13.4.688-695.1981"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.3.749-757.2000"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-006-9057-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.19.6212-6219.1993"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242338299"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.11.027"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/349117a0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(03)00037-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2006.09.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889893005588"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444905036693"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"Collaborative Computational Project No. 4 (1994). 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