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To date these models have implicated RyRs in fundamental biological processes including excitation\u2013contraction coupling and long term plasticity as well as diseases including malignant hyperthermia, cardiac arrhythmias, heart failure, and seizures. In this review we summarize the RyR mouse models and how they have enhanced our understanding of the RyR channels and their roles in cellular physiology and disease.<\/jats:p>","DOI":"10.1016\/j.febslet.2010.03.005","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T09:46:57Z","timestamp":1268128017000},"page":"1956-1965","source":"Crossref","is-referenced-by-count":49,"title":["Ryanodine receptor studies using genetically engineered mice"],"prefix":"10.1002","volume":"584","author":[{"given":"Alexander","family":"Kushnir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Betzenhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/369556a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.12.3309"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07302.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.5.893"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.19.5264"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.142"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00955-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1205739"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2536"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8683"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/339439a0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39968-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80399-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)77371-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80941-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.053105.094237"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(97)78166-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012688999"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106471200"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/415198a"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/351751a0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.85.2.247"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900202"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00349a033"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.36831"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29515"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(95)79880-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61469-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.4.699"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90214-3"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80847-8"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1101.091268"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2004.06.003"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.10.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99140-4"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(95)90064-0"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm038"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902919106"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.022442"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.654699"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602004000400015"},{"key":"e_1_2_8_44_1","first-page":"2984","article-title":"Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle","volume":"44","author":"Sutko J.L.","year":"1985","journal-title":"Fed. 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