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In turn, organ disease may influence the function of clock genes and peripheral circadian systems. Here we showed that hepatic fibrosis induced by carbon tetrachloride in mice leads to alterations in the circadian rhythms of hepatic clock genes. Especially, we found an impaired daily\n                    <jats:italic>Cry2<\/jats:italic>\n                    rhythm in the fibrotic livers, with markedly decreased levels during the day time while compared with control livers. Associatively, the expressions of two important clock\u2010regulated genes peroxisome proliferator\u2010activated receptor alpha and cytochrome P450 oxidoreductase lost circadian rhythm with significantly decreased levels during the light\u2013dark (12\/12 h) cycle in fibrotic livers.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2010.03.019","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T04:33:25Z","timestamp":1268714005000},"page":"1597-1601","source":"Crossref","is-referenced-by-count":44,"title":["Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon 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