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Cholera poses a particular threat, and the need to develop better intervention tools is imminent. Cholera infections are particularly severe for blood group O individuals, who are less protected by the current vaccines. Here we derive a hypothesis as to the molecular origins of blood\u2010group dependence of this disease, based on relevant epidemiological, clinical and molecular data, and give suggestions on how to plan prevention strategies, and develop novel and improved pharmaceuticals.<\/jats:p>","DOI":"10.1016\/j.febslet.2010.03.050","type":"journal-article","created":{"date-parts":[[2010,4,23]],"date-time":"2010-04-23T08:51:25Z","timestamp":1272012685000},"page":"2548-2555","source":"Crossref","is-referenced-by-count":30,"title":["Molecular basis of cholera blood\u2010group dependence and implications for a world characterized by climate change"],"prefix":"10.1002","volume":"584","author":[{"given":"\u00c5sa","family":"Holmner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasdair","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Krengel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15328-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.45.1.275-283.1983"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.56.6.1977-1980.1990"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1995.tb00182.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2005.00771.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705599104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2007.tb03924.x"},{"key":"e_1_2_9_9_1","unstructured":"WHO (2010). &lt;http:\/\/www.who.int\/topics\/cholera\/en\/&gt;."},{"key":"e_1_2_9_10_1","unstructured":"WHO (2009). 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