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In the present study we investigated whether apelin affects ROS\u2010dependent cardiac hypertrophy. In cardiomyocytes apelin inhibited the hypertrophic response to 5\u2010HT and oxidative stress induced by 5\u2010HT\u2010 or H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in a dose\u2010dependent manner. These effects were concomitant to the increase in mRNA expression and activity of catalase. Chronic treatment of mice with apelin attenuated pressure\u2010overload\u2010induced left ventricular hypertrophy. The prevention of hypertrophy by apelin was associated with increased myocardial catalase activity and decreased plasma lipid hydroperoxide, as an index of oxidative stress. 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