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Moreover, the G residues are concentrated in the strand running 3\u2032\u20135\u2032 from the end of the chromosome towards its center. This G\u2010rich strand is extended to form a 3\u2032 single\u2010stranded tail that can form unusual secondary structures such as T\u2010loops and G\u2010quadruplex DNA. Both the duplex repeats and the single\u2010stranded G\u2010tail are assembled into stable protein\u2013DNA complexes. The unique architecture, high GC content, and multi\u2010protein association create particularly stable protein\u2013DNA complexes that are a challenge for replication, recombination, and transcription. Helicases utilize the energy of nucleotide hydrolysis to unwind base paired nucleic acids and, in some cases, to displace proteins from them. The telomeric functions of helicases from the RecQ, Pifl, FANCJ, and DNA2 families are reviewed in this article. 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