{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:49:04Z","timestamp":1791290944083,"version":"4.3.0"},"reference-count":12,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:00:00Z","timestamp":1280188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Commission integrated project","award":["LSHM-CT-2004-005272\/"],"award-info":[{"award-number":["LSHM-CT-2004-005272\/"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2010,8,20]]},"abstract":"<jats:p>AMP\u2010activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPK\u03b11\u2212\/\u2212 mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPK\u03b11\u2212\/\u2212 mice worsened anemia supporting evidence that AMPK\u03b11\u2212\/\u2212 mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPK\u03b11\u2212\/\u2212 mice into wild\u2010type recipients recapitulated the hematologic phenotype. Further, AMPK\u03b11\u2212\/\u2212 red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.<\/jats:p>","DOI":"10.1016\/j.febslet.2010.07.041","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T08:40:51Z","timestamp":1280306451000},"page":"3667-3671","source":"Crossref","is-referenced-by-count":29,"title":["Maintenance of red blood cell integrity by AMP\u2010activated protein kinase \u03b11 catalytic subunit"],"prefix":"10.1002","volume":"584","author":[{"given":"Marc","family":"Foretz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soizic","family":"Guihard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Leclerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Fauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Couty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Andris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Gaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Andreelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Vaulont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Viollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2006.00205.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.01.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1622"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086406"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121772"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.102467"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738045"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306205200"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-119057"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151179498"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.084"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2010.07.041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2010.07.041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2010.07.041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T16:09:30Z","timestamp":1698682170000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2010.07.041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,27]]},"references-count":12,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,8,20]]}},"alternative-id":["10.1016\/j.febslet.2010.07.041"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2010.07.041","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,27]]}}}