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This review focuses on a newly characterized hematopoietic cell\u2010specific actin regulatory protein called hematopoietic protein\u20101 [Hem\u20101, also known as Nck\u2010associated protein 1\u2010like (Nckap1l or Nap1l)]. Hem\u20101 is a component of the \u201cWAVE [WASP (Wiskott\u2010Aldrich syndrome protein)\u2010family verprolin homologous protein]\u201d complex, which signals downstream of activated Rac to stimulate F\u2010actin polymerization in response to immuno\u2010receptor signaling. Genetic studies in cell lines and in mice suggest that Hem\u20101 regulates F\u2010actin polymerization in hematopoietic cells, and may be essential for most active processes dependent on reorganization of the actin cytoskeleton in immune cells.<\/jats:p>","DOI":"10.1016\/j.febslet.2010.10.018","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T09:25:32Z","timestamp":1287653132000},"page":"4923-4932","source":"Crossref","is-referenced-by-count":36,"title":["Hem\u20101: Putting the \u201cWAVE\u201d into actin polymerization during an immune response"],"prefix":"10.1002","volume":"584","author":[{"given":"Heon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia M.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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