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UV treatment led to c\u2010Jun N\u2010terminal kinase (JNK) phosphorylation, Bim redistribution and subsequent Bax activation. Bim depletion caused a smaller reduction in apoptosis than that by JNK inhibition, indicating that Bim activation is not entirely responsible for induction of apoptosis and other mechanisms are involved. Hsp70 knockdown resulted in high levels of activated JNK and Bax, while Hsp70 overexpression inhibited these processes. These findings demonstrate that Hsp70 prevented Bax activation via inhibiting the JNK\/Bim pathway. Simultaneously, increased binding of Hsp70 to Bax was observed. Collectively, our results for the first time demonstrate that Hsp70 prevents Bax activation both by inhibiting the JNK\/Bim pathway and by interacting with Bax in UV\u2010induced apoptosis.<\/jats:p>","DOI":"10.1016\/j.febslet.2010.10.050","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T08:16:52Z","timestamp":1288253812000},"page":"4672-4678","source":"Crossref","is-referenced-by-count":36,"title":["Inhibition of the JNK\/Bim pathway by Hsp70 prevents Bax activation in UV\u2010induced apoptosis"],"prefix":"10.1002","volume":"584","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei R.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1194"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02040.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1322"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059108"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0438011100"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00116-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1492"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)41621-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.5.1947"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(1998)003<0228:HSPROS>2.3.CO;2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306167"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1799"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509497200"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401369"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2041"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4751-08.2008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.04.045"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.167"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-11-1109"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0091-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-008-0226-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35019501"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-27R1.1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513728200"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35060068"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200409117"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.03.025"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23378"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200210140"},{"key":"e_1_2_7_31_1","first-page":"777","article-title":"Radio resistance is associated to increased Hsp70 content in human glioblastoma cell lines","volume":"25","author":"Brondani Da Rocha A.","year":"2004","journal-title":"Int. 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