{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:56:04Z","timestamp":1790391364559,"version":"4.1.0"},"reference-count":91,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2011,5,20]]},"abstract":"<jats:p>The zebrafish represents a fascinating model for studying key aspects of the vertebrate circadian timing system. Easy access to early embryonic development has made this species ideal for investigating how the clock is first established during embryogenesis. In particular, the molecular basis for the functional development of the zebrafish pineal gland has received much attention. In addition to this dedicated clock and photoreceptor organ, and unlike the situation in mammals, the clocks in zebrafish peripheral tissues and even cell lines are entrainable by direct exposure to light thus providing unique insight into the function and evolution of the light input pathway. Finally, the small size, low maintenance costs and high fecundity of this fish together with the availability of genetic tools make this an attractive model for forward genetic analysis of the circadian clock. Here, we review the work that has established the zebrafish as a valuable clock model organism and highlight the key questions that will shape the future direction of research.<\/jats:p>","DOI":"10.1016\/j.febslet.2011.04.007","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T14:57:38Z","timestamp":1302879458000},"page":"1485-1494","source":"Crossref","is-referenced-by-count":276,"title":["It's time to swim! Zebrafish and the circadian clock"],"prefix":"10.1002","volume":"585","author":[{"given":"Gad","family":"Vatine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Gothilf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.02.028"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.02.027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123.1.1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00048-8"},{"key":"e_1_2_9_6_1","unstructured":"C. N&uuml;sslein-Volhard R. Dahm 2002 Oxford University Press Oxford"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908247106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp091"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082615sb"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0570-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01365-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35003589"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5343.1632"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2007.72.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2007.72.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-120022415"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58932-4_1"},{"key":"e_1_2_9_18_1","first-page":"21","article-title":"Melatonin and neuroendocrine regulations in fish","volume":"201","author":"Falcon J.","year":"2007","journal-title":"J. Soc. Biol."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00993.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.10.4895"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.09.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.01893"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2741\/1196"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00965"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0498-345"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2000.00364.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704588104"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.margen.2008.06.003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10709-008-9328-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg174"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2002.00579.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-008-9121-5"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600571103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2005.01315.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/3703"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4339"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00325-X"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.03.051"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00183-8"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199810260-00020"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/01677060490894540"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(99)00096-6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1996.6828"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030034"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-257-1_38"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/01677060802049738"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80245-7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01225-4"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81199-X"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305436101"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1232"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606563103"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(03)00059-7"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.05.020"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5427.553"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00835-7"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705614104"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.17.9447"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102075599"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000223"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2010.510229"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1738"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.6.679"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.13.4773-4781.2000"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.10.048"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.1183"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502610102"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.01.014"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800052200"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012542"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017080"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5477.297"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.183"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-133X(03)00050-4"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.10.022"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1565"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00380-4"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873001129001791"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086271"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050078"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5488.2344"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00758-2"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0439"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412935200"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp031"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030351"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520902765928"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420520903232092"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.05.015"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10152"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181228598"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2011.04.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2011.04.007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2011.04.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T12:33:29Z","timestamp":1694954009000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2011.04.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,7]]},"references-count":91,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,5,20]]}},"alternative-id":["10.1016\/j.febslet.2011.04.007"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2011.04.007","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,7]]}}}