{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:49:32Z","timestamp":1789753772059,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T00:00:00Z","timestamp":1312588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T00:00:00Z","timestamp":1312588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,2]]},"DOI":"10.1016\/j.febslet.2011.07.046","type":"journal-article","created":{"date-parts":[[2011,8,7]],"date-time":"2011-08-07T23:17:31Z","timestamp":1312759051000},"page":"2755-2762","source":"Crossref","is-referenced-by-count":96,"title":["Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-\u03baB and ERK activation"],"prefix":"10.1002","volume":"585","author":[{"given":"Estabelle S.M.","family":"Ang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming H.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiake","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,6]]},"reference":[{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0005|feb2s0014579311005898-cit-b0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0010|feb2s0014579311005898-cit-b0010","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1359\/jbmr.2000.15.11.2178","article-title":"Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand","volume":"15","author":"Xu","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0015|feb2s0014579311005898-cit-b0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S8756-3282(99)00105-2","article-title":"Required and nonessential functions of nuclear factor-kappa B in bone cells","volume":"25","author":"Boyce","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0020|feb2s0014579311005898-cit-b0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cytogfr.2008.11.007","article-title":"NF-kappaB modulators in osteolytic bone diseases","volume":"20","author":"Xu","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0025|feb2s0014579311005898-cit-b0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1021\/tx00016a015","article-title":"Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene","volume":"3","author":"Guengerich","year":"1990","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0030|feb2s0014579311005898-cit-b0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1383-5718(02)00111-0","article-title":"The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study","volume":"519","author":"Jagetia","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0035|feb2s0014579311005898-cit-b0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/mutage\/geg001","article-title":"Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow","volume":"18","author":"Jagetia","year":"2003","journal-title":"Mutagenesis"},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0040|feb2s0014579311005898-cit-b0040","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/mutage\/gen045","article-title":"Abatement by naringin of lomefloxacin-induced genomic instability in mice","volume":"23","author":"Attia","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0045|feb2s0014579311005898-cit-b0045","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1142\/S0192415X07005156","article-title":"Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model","volume":"35","author":"Wei","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0050|feb2s0014579311005898-cit-b0050","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.phymed.2008.09.001","article-title":"Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats","volume":"16","author":"Mandadi","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0055|feb2s0014579311005898-cit-b0055","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1128\/MCB.25.12.5253-5269.2005","article-title":"Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption","volume":"25","author":"Pavlos","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0060|feb2s0014579311005898-cit-b0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jcb.22800","article-title":"Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-kappaB and ERK","volume":"112","author":"Ang","year":"2011","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0065|feb2s0014579311005898-cit-b0065","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2353\/ajpath.2006.050960","article-title":"P62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget’s disease of bone","volume":"169","author":"Yip","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0070|feb2s0014579311005898-cit-b0070","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jcp.21898","article-title":"Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity","volume":"221","author":"Ang","year":"2009","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0075|feb2s0014579311005898-cit-b0075","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jcp.21076","article-title":"Calcium\/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL)","volume":"212","author":"Ang","year":"2007","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0080|feb2s0014579311005898-cit-b0080","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1359\/jbmr.2003.18.12.2159","article-title":"12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation","volume":"18","author":"Wang","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0085|feb2s0014579311005898-cit-b0085","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0090|feb2s0014579311005898-cit-b0090","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1359\/jbmr.2002.17.4.612","article-title":"Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand","volume":"17","author":"Yamamoto","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0095|feb2s0014579311005898-cit-b0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1074\/jbc.M008198200","article-title":"Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0100|feb2s0014579311005898-cit-b0100","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","article-title":"Requirement for NF-kappaB in osteoclast and B-cell development","volume":"11","author":"Franzoso","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0105|feb2s0014579311005898-cit-b0105","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0110|feb2s0014579311005898-cit-b0110","doi-asserted-by":"crossref","first-page":"47366","DOI":"10.1074\/jbc.M208284200","article-title":"U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells","volume":"277","author":"Hotokezaka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0115|feb2s0014579311005898-cit-b0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-5793(00)02231-6","article-title":"Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor","volume":"486","author":"Matsumoto","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0120|feb2s0014579311005898-cit-b0120","doi-asserted-by":"crossref","first-page":"31155","DOI":"10.1074\/jbc.M001229200","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)","volume":"275","author":"Matsumoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0125|feb2s0014579311005898-cit-b0125","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/sj.bjp.0702357","article-title":"Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol","volume":"126","author":"Tsai","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0130|feb2s0014579311005898-cit-b0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0014-2999(98)00867-X","article-title":"Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin","volume":"368","author":"Kawaguchi","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0135|feb2s0014579311005898-cit-b0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2004-815449","article-title":"Suppression of infection-induced endotoxin shock in mice by a citrus flavanone naringin","volume":"70","author":"Kawaguchi","year":"2004","journal-title":"Planta Med."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0140|feb2s0014579311005898-cit-b0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.lfs.2005.04.051","article-title":"Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages","volume":"78","author":"Kanno","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0145|feb2s0014579311005898-cit-b0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0150|feb2s0014579311005898-cit-b0150","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2362.2007.01800.x","article-title":"Alteration of bone cell function by RANKL and OPG in different in vitro models","volume":"37","author":"Lin","year":"2007","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.febslet.2011.07.046-BIB2s0014579311005898-bib-b0155|feb2s0014579311005898-cit-b0155","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2174\/138955706777934937","article-title":"Naturally occurring NF-kappaB inhibitors","volume":"6","author":"Nam","year":"2006","journal-title":"Mini Rev. Med. Chem."}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2011.07.046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2011.07.046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1016\/j.febslet.2011.07.046\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T09:15:57Z","timestamp":1599556557000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1016\/j.febslet.2011.07.046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,6]]},"references-count":31,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2011,9,2]]}},"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2011.07.046","archive":["Portico"],"relation":{},"ISSN":["0014-5793"],"issn-type":[{"value":"0014-5793","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8,6]]}}}