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SB\u2010204741 treatment significantly ameliorated (<jats:italic>P<\/jats:italic>\n&lt; 0.05) myocardial dysfunction, myocyte area, fibrosis and myocardial architecture in isoproterenol insulted myocardium. Moreover, this improvement in functional and morphological changes was associated with suppression of hypertrophic (BNP and CK\u2010MB), inflammatory (IKK\u2010\u03b2\/NF\u2010\u03baB\/TNF\u2010\u03b1 and CRP), and apoptotic markers (TUNEL positivity and Bax expression) along with phosphorylation of Akt\/GSK\u20103\u03b2\/\u03b2\u2010catenin\/eNOS. Intriguingly, co\u2010treatment with GSK\u20103\u03b2 inhibitor (<jats:italic>P<\/jats:italic>\n&lt; 0.01) further amplified the anti\u2010hypertrophic effect of SB\u2010204741 (<jats:italic>P<\/jats:italic>\n&lt; 0.05) such that the effect was indistinguishable from that of vehicle treated rats. Thus, 5\u2010HT<jats:sub>2B<\/jats:sub> receptor blockade mediated anti\u2010hypertrophic effect is atleast in part is governed through phosphorylation of Akt\/GSK\u20103\u03b2\/\u03b2\u2010catenin\/eNOS via attenuating inflammatory and apoptotic pathways.<\/jats:p>","DOI":"10.1016\/j.febslet.2011.12.015","type":"journal-article","created":{"date-parts":[[2011,12,26]],"date-time":"2011-12-26T12:43:47Z","timestamp":1324903427000},"page":"180-185","source":"Crossref","is-referenced-by-count":14,"title":["Phosphorylation of Akt\/GSK\u20103\u03b2\/eNOS amplifies 5\u2010HT<sub>2B<\/sub> receptor blockade mediated anti\u2010hypertrophic effect in rats"],"prefix":"10.1002","volume":"586","author":[{"given":"Saurabh","family":"Bharti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratnakar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajamul","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar S.","family":"Al-Attas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharamvir Singh","family":"Arya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.197996"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.06.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.105551"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05388.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.138008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01377.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000106132.04301.F5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401413200"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000338259.37472.b6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02157-05"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000266605.63681.5a"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-007-0028-y"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200805063"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051265"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.09.009"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn243"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.07.006"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002178107"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1047"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.08.003"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2011.12.015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2011.12.015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2011.12.015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T02:14:32Z","timestamp":1698632072000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2011.12.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,26]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1,20]]}},"alternative-id":["10.1016\/j.febslet.2011.12.015"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2011.12.015","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,26]]}}}