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Cycloheximide and Brefeldin A treatment revealed both the expression of S100A8 and S100A9 as secondary response genes and the involvement of polyI:C\u2010induced cytokines herein. Several type I and type III interferons such as IFN\u03b2, IL\u201020, IL\u201024, and IFN\u03bb\/IL\u201029 were expressed in response to polyI:C, however, they failed to induce S100A8 and S100A9 gene expression. 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