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In addition, estrogenic ethanol was able to stimulate cyclin E truncation. Calpeptin or ALLN greatly suppressed the E2\u2010triggered cyclin E processing and its expression, suggesting a calpain\u2010mediated action for E2. Finally, the E2\u2010induced effects could also be significantly suppressed by BAPTA or U0126, indicating involvement of calcium\/ERK signaling. Taken together, these results show that estrogen may contribute to both up\u2010regulation and proteolysis of cyclin E through calpain in MCF\u20107 cells.<\/jats:p>","DOI":"10.1016\/j.febslet.2012.02.018","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T17:45:39Z","timestamp":1330451139000},"page":"892-896","source":"Crossref","is-referenced-by-count":8,"title":["17beta\u2010estradiol induces both up\u2010regulation and processing of cyclin E in a calpain\u2010dependent manner in MCF\u20107 breast cancer 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