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We earlier reported that LMP2\u2010null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti\u2010tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2\u2010induced cellular morphological changes. 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