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Moreover, such mutations cause also hyperosmotic sensitivity and the underlying mechanism has been elusive for a long time. Using <jats:italic>Saccharomyces cerevisiae<\/jats:italic> as an experimental host, we show that those phenotypes are conferred by a constitutively active form of the group III histidine kinase. Our results explain the different reasons for fludioxonil resistance conferred by its deletion and missense mutation.<\/jats:p>","DOI":"10.1016\/j.febslet.2012.05.057","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T21:23:10Z","timestamp":1339190590000},"page":"2417-2422","source":"Crossref","is-referenced-by-count":76,"title":["Fungal fludioxonil sensitivity is diminished by a constitutively active form of the group III histidine kinase"],"prefix":"10.1002","volume":"586","author":[{"given":"Kentaro","family":"Furukawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmoldeep","family":"Randhawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsimran","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok K.","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.2.300-372.2002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00323-08"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)28002-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.05.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80162-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/369242a0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.11.5304-5310.2002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.6.1151-1161.2003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.11.1820-1828.2005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.075721"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.66.2209"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-005-0572-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E06-02-0113"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70051"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.2.532-538.2002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04244.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70131"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.302"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-003-0974-4"},{"key":"e_1_2_7_21_1","unstructured":"D.C. 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